estradiol

Estradiol Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

[1. the most potent naturally occurring estrogen in mammals, formed by the ovary, placenta, testis, and possibly the adrenal cortex; therapeutic indications for estradiol are those typical of an estrogen. α-Estradiol (17α-estradiol), exhibits considerably less biologic activity.

Molecular Formula: C₁₈H₂₄O₂

InChI: InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3

InChIKey: InChIKey=VOXZDWNPVJITMN-UHFFFAOYAT
SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

Names:
    estradiol
    Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-
    13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Registries:
    PubChem CID 450
    PubChem ID 10468968