metyrapone

Metyrapone An inhibitor of the enzyme STEROID 11 BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.

[1. An inhibitor of adrenocortical steroid C-11 β-hydroxylation, administered orally or intravenously to determine the ability of the pituitary gland to increase its secretion of corticotropin; because 11-deoxycorticosteroids, as a consequence of metyrapone administration, only weakly inhibit pituitary corticotropin secretion, the normal pituitary gland will appreciably increase its output of this hormone.

Molecular Formula: C₁₄H₁₄N₂O

InChI: InChI=1/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3

InChIKey: InChIKey=FJLBFSROUSIWMA-UHFFFAOYAJ
SMILES: CC(C)(C1=CC=CN=C1)C(=O)C2=CC=CN=C2

CAS number 54-36-4

Names:
    METOPIRONE (TN)
    metyrapone
    Metyrapone
    METYRAPONE
    Metyrapone
    metyrapone
    1-Propanone, 2-methyl-1,2-di-3-pyridinyl-
    2-methyl-1,2-dipyridin-3-yl-propan-1-one

Registries:
    PubChem CID 4174
    Beilstein =163023
    CAS 54-36-4 (from NIST)
    ChEBI 6911
    chemPDB MYT
    Kegg C07205
    Kegg D00410
    PubChem ID 10396161
    PubChem ID 9414