Propiocine

Erythromycin A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

[1. A macrolide antibiotic agent obtained from cultures of a strain of Streptomyces erythraeus found in soil; it is active against Corynebacterium diphtheriae and several other species of Corynebacterium, Group A hemolytic streptococci, Streptococcus pneumoniae, Legionella, Mycoplasma pneumoniae, and Bordetella pertussis; gram-positive bacteria are in general more susceptible to its action than gram-negative bacteria are. Available as the estolate, ethylcarbonate, ethylsuccinate, gluceptate, lactobionate, stearate, and salts; active against Legionella and Mycoplasma pneumoniae. Often used as a substitute antibiotic in penicillin-allergic patients.

Molecular Formula: C₃₇H₆₇NO₁₃

InChI: InChI=1/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3

InChIKey: InChIKey=ULGZDMOVFRHVEP-UHFFFAOYAC
SMILES: CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O

Names:
    Abboticin
    Erycinum
    Erythrocin
    Erythrogran
    Erythromid
    erythromycin
    Ilotycin
    Pantomicina
    Pediamycin
    Propiocine
    6-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione

Registries:
    PubChem CID 3255
    PubChem ID 105539