dopamine

[(Science: drug) a catecholamine neurotransmitter and hormone (153 D), formed by decarboxylation of dehydroxyphenylalanine (dopa). a precursor of adrenaline and noradrenaline. pharmacologic action: 1. precursor of norepinephrine 2. stimulates dopaminergic, alpha and beta-1 adrenergic receptors: 3. dopaminergic (1-2 mcg/kg per min): cerebral, renal, and mesenteric vasodilation increase urine output 4. mixed alpha and beta-1 (2-10 mcg/kg per min): increases cardiac ouput with moderate increase systemic vascular resistance 5. Predominantly alpha (>20 mcg/kg per min): increases systemic vascular resistance Uses: 1. treat hypotension associated with bradycardia 2. stimulate cardiac output and urine output Dose: 1. start infusion at 1-5 mcg/kg per min and titrate to effect. 2. use the lowest dose that provides the desired hemodynamic improvement. 3. Do not exceed 20 mcg/kg per min. potential complications: 1. May increase pulmonary pressure and worsen pu

[1. An intermediate in tyrosine metabolism and precursor of norepinephrine and epinephrine; neurotransmitter is the peripheral and central nervous systems; depletion of dopamine produces Parkinson disease.