Sodium acetazolamide

Acetazolamide One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Molecular Formula: C₄H₅N₄NaO₃S₂

InChI: InChI=1/C4H6N4O3S2.Na/c1-2(9)6-3-7-8-4(12-3)13(5,10)11;/h1H3,(H3,5,6,7,9,10,11);/q;+1/p-1/fC4H5N4O3S2.Na/h5-6H;/q-1;m

InChIKey: InChIKey=MRSXAJAOWWFZJJ-SIGQEMJBCA
SMILES: CC(=O)NC1=NN=C(S1)S(=O)(=O)[NH-].[Na+]

Names:
    ACETAMIDE, N-(5-SULFAMOYL-1,3,4-THIADIAZOL-2-YL)-, MONOSODIUM SALT
    Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-, monosodium salt
    Acetazolamide sodium salt
    Acetazolamide sodium [USAN:JAN]
    Acetazolamide sodium
    Diamox sodium
    N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide monosodium salt
    Sodium acetazolamide
    sodium (5-acetamido-1,3,4-thiadiazol-2-yl)sulfonylazanide
    1424-27-7
    59-66-5

Registries:
    PubChem CID 15021
    PubChem ID 158345