VePesid

Etoposide A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

[(Science: drug, oncology) etoposide is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It may be administered either intravenously or orally. side effects: low blood counts and chance of allergic reactions.

Molecular Formula: C₂₉H₃₂O₁₃

InChI: InChI=1/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChIKey: InChIKey=VJJPUSNTGOMMGY-MRVIYFEKBZ
SMILES: [H][C@]12COC(=O)[C@]1([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=C(C=C5OCOC5=C4)[C@H]2O[C@@H]6O[C@@H]7CO[C@@H](C)O[C@H]7[C@H](O)[C@H]6O

Names:
    EPEG
    Etopol
    Etopophos
    etoposide
    Etoposide
    etoposide
    Etosid
    Lastet
    NSC-141540
    Vepeside
    VePesid
    VP-16
    4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)
    9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-

Registries:
    PubChem CID 36462
    ChEBI 4911
    Kegg C01576
    PubChem ID 12013288
    PubChem ID 4733