Tirian hydrochloride

PubChem Notes:

Chloroguanide A biguanide compound which has little antimalarial activity until metabolized in the body to the active antimalarial agent cycloguanil. The usefulness of proguanil is limited by the rapid development of drug resistance by the malarial parasite. The hydrochloride is used for the casual prophylaxis of falciparum malaria, to suppress other forms of malaria, and to reduce transmission of infection (From Martindale, The Extra Pharmacopoeia, 30th ed, p405)

Molecular Formula: C11H17Cl2N5


InChI: InChI=1/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H/f/h16H,13-14H2;/b15-10+,17-11+;

InChIKey: InChIKey=SARMGXPVOFNNNG-JEKZXIGGDP
SMILES: CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl.Cl

Names:
    Bigumalum
    Chlorguanide hydrochloride
    Chloroquanil
    Diguanyl
    Drinupal hydrochloride
    Guanatol hydrochloride
    Paludrine
    Palusil hydrochloride
    Proguanil hydrochloride
    Tirian hydrochloride
    (1E)-1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-yl-guanidine hydrochloride

Registries:
    PubChem CID 9570076
    PubChem ID 155818