rifampin

PubChem Notes:

Rifampin A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Molecular Formula: C42H56N4O13


InChI: InChI=1/C42H56N4O13/c1-20-11-10-12-21(2)40(53)44-31-26(19-43-46-16-14-45(8)15-17-46)35(50)28-29(36(31)51)34(49)25(6)38-30(28)39(52)42(7,59-38)57-18-13-27(56-9)22(3)37(58-41(54)55)24(5)33(48)23(4)32(20)47/h10-13,18-20,22-24,27,32-33,37,43,47-49,51H,14-17H2,1-9H3,(H,44,53)(H,54,55)/b11-10+,18-13+,21-12+,26-19+/t20-,22-,23+,24-,27-,32-,33+,37+,42-/m0/s1/f/h44,54H

InChIKey: InChIKey=JBDVXWDFDCWBIG-IAKJEIIMDG
SMILES: CC1C=CC=C(C(=O)NC2=C(C3=C(C(=C4C(=C3C(=O)C2=CNN5CCN(CC5)C)C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)O)C)OC)C)C)O)O)C

Names:
    CHEBI:28077
    Rifampicin
    rifampin
    (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl
    3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV

Registries:
    PubChem CID 6857374
    PubChem ID 11533154