VLB
Vinblastine - definition from Biology-Online.org
[(Science: drug, oncology) alkaloid (818D) isolated from Vinca (periwinkle): binds to tubulin heterodimer and induces formation of paracrystals rather than tubules. net result is that microtubules disappear as they disassemble and are not replaced. Used in tumour chemotherapy.
Molecular Formula:
C46H58N4O9
InChI: InChI=1/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
InChIKey: InChIKey=JXLYSJRDGCGARV-XQKSVPLYBI
SMILES: [H][C@@]12N(C)c3cc(OC)c(cc3[C@@]14CCN5CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]2(O)C(=O)OC)[C@@]45[H])[C@]6(C[C@@H]7C[N@H](CCc8c6[nH]c9ccccc89)C[C@](O)(CC)C7)C(=O)OC
CAS number 865-21-4
Names:
NCI60_004200
Vinblastine
vincaleukoblastine
VLB
(2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
Registries:
PubChem CID 241903
Beilstein =4779207
CAS 865-21-4 (from NIST)
ChEBI 27375
chemPDB VLB
Kegg C07201
PubChem ID 11408591
PubChem ID 9410
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