Methylaminopterin
PubChem Notes:
Methotrexate An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
MediLexicon methotrexate - Medical Dictionary Definition for Term 'methotrexate'
[1. A folic acid antagonist used as an antineoplastic agent; used to treat psoriasis and rheumatoid arthritis.
Molecular Formula:
C20H22N8O5
InChI: InChI=1/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/f/h25,29,32H,21-22H2
InChIKey: InChIKey=FBOZXECLQNJBKD-MLCQBUKUCS
SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Names:
Amethopterin
CL 14377
EMT 25,299
Hdmtx
Metatrexan
Methopterin
methotrexate
Methylaminopterin
NCI-C04671
NSC740
2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioic acid
Registries:
PubChem CID 4112
PubChem ID 67627
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