tetragastrin

Tetragastrin L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.

[1. A tetrapeptide (Trp–Met–Asp–Phe–NH2) used to test the secretion of digestive juice.2. A pterin derivative that is a required cofactor for a number of enzymes; in the conversion of l-phenylalanine to l-tyrosine; the inability to synthesize tetrahydrobiopterin is associated with forms of malignant hyperphenylalaninemia.

Molecular Formula: C₃₇H₄₂N₆O₈S

InChI: InChI=1/C37H42N6O8S/c1-52-17-16-28(34(47)42-31(20-32(44)45)36(49)41-29(33(38)46)18-23-10-4-2-5-11-23)40-35(48)30(19-25-21-39-27-15-9-8-14-26(25)27)43-37(50)51-22-24-12-6-3-7-13-24/h2-15,21,28-31,39H,16-20,22H2,1H3,(H2,38,46)(H,40,48)(H,41,49)(H,42,47)(H,43,50)(H,44,45)/f/h40-44H,38H2

InChIKey: InChIKey=DLOHHVQNOMRHQK-CZNQRIDWCD
SMILES: CSCCC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4

Names:
    CCRIS 3246
    Cholecystokinin tetrapeptide
    Gastrin tetrapeptide amide
    Gastrin tetrapeptide
    L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-alpha-aspartyl-
    L-Phenylalaninamide, N-((phenylmethoxy)carbonyl)-L-tryptophyl-L-methionyl-L-aspartyl-
    L-Triptophyl-L-methyionyl-L-alpha-aspartyl-L-phenylalaninamide
    N-((Phenylmethoxy)carbonyl)-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide
    Tetragastrin [JAN]
    tetragastrin
    3-[(1-carbamoyl-2-phenyl-ethyl)carbamoyl]-3-[[2-[[3-(1H-indol-3-yl)-2-phenylmethoxycarbonylamino-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]propanoic acid

Registries:
    PubChem CID 5415
    PubChem ID 159319