Tropine tropate

[(Science: drug) a toxic alkaloid extracted from belladonna and other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms. pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. increases sinus node automaticity and av conduction. Uses: treat bradycardia, asystole, and av block Dose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 ml sterile water or normal saline. potential complications: 1. Tachyarrhythmias 2. exacerbation of myocardial ischemia 3. low dose may cause paradoxical bradycardia 4. dry mouth, urinary retention, flushed and hot skin 5.

[1. A racemic mixture of d- and l- hyoscyamine, alkaloids obtained from the leaves and roots of Atropa belladonna; an anticholinergic, with diverse effects (tachycardia, mydriasis, cycloplegia, constipation, urinary retention, antisudorific) attributable to reversible competitive blockade of acetylcholine at muscarinic type cholinergic receptors; most commonly used in the treatment of poisoning with organophosphate insecticides or nerve gases, as well as certain types of bradydysrhythmias and to prevent secretions during preparation for general anesthesia. The (–) form is by far the more active.